- Mouse Anti-DOG-1/TMEM16A Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS4380182
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Monoclonal
- Human. Others not known
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
- Mouse
- ~114kDa
- DOG-1/TMEM16A
- anoctamin 1
- TMEM16A, ORAOV2, TAOS2, DOG1
- Unconjugated
- IgG2b kappa
- DG1/1485
Specifications/Features
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%